Prescription RequiredHair Loss Treatment

Topical Dutasteride

Sale price$129.00 per month

(Delivered every 3 months)

Topical dutasteride from XYON stops thinning hair in its tracks and promotes hair regrowth. Formulated with dutasteride, clinically shown to be effective in treating hair loss. Delivered using an advanced doctor-formulated, timed-release gel designed to minimize absorption of medication into the body and lower the risk of sexual side effects of dutasteride. Dermatologist tested.

Safety Information

Before you start using dutasteride and each time you get a refill, please review this important safety information. This information may be updated. It does not replace discussing your medical condition or treatment with your doctor or healthcare provider.

What is the FDA approved use of dutasteride?

Dutasteride is FDA approved as an oral medication to treat benign prostatic hyperplasia (Proscar) in men. Dutasteride has not been FDA approved for topical use or specifically for use in women, but it may be prescribed off-label in topical compounded formulations for hair loss.

You can read more about some of the study data on dutasteride use in women by visiting this link:

Adverse effects and safety of 5-alpha reductase inhibitors finasteride and dutasteride: A systematic review.

What is topical dutasteride?

Topical dutasteride is a compounded prescription medication used for the treatment of male and female pattern hair loss (androgenetic alopecia). This compounded treatment is not approved by the FDA and is only available if prescribed after an online consultation with a licensed physician through the XYON Health platform. Data from small scale and case studies have shown that topical dutasteride may help reduce serum DHT levels with a lower incidence of side effects (e.g., sexual dysfunction) that have been reported with the oral versions of this class of medications.

What should I tell my healthcare provider before taking dutasteride?

Please inform your doctor or healthcare provider if any of the following apply:

  • You have a personal or family history of prostate cancer, breast cancer
  • You have prostate or urinary symptoms such as reduced urine flow, difficulty urinating or pain
  • You have a history of liver or kidney disease or dysfunction
  • You have a history of any serious mental health conditions
  • You are pregnant, trying to get pregnant, or are breastfeeding

Who should not take dutasteride?

You should not take dutasteride if you:

  • Have ever had an allergic reaction to dutasteride or any other ingredients in the treatment
  • Have a history of liver disease or dysfunction
  • Dutasteride should not be used by women who are pregnant, may be pregnant or are breastfeeding
  • Dutasteride should not be used by infants or children

What are the possible side effects of dutasteride?

The following side effects have been reported with dutasteride use:

  • Breast tenderness and enlargement. You should inform your doctor or healthcare provider if you notice any breast lumps, pain or nipple discharge
  • Depression, anxiety, brain fog, suicidal ideation
  • Decrease libido (sex drive)
  • Allergic reactions (e.g., rash, itching, hives and swelling of the lips, tongue, throat, and face)
  • Problems with ejaculation
  • Testicular pain
  • Erectile dysfunction (difficulty achieving or maintaining an erection)
  • Male infertility and/or poor semen quality

Please note that dutasteride has only been formally studied in male patients so the side effect profile above is specific to clinical studies in men.

Preliminary data on the use of dutasteride in female patients has shown the following possible side effects:

  • Decreased libido (sex drive)
  • Breast tenderness and enlargement
  • Mood changes (e.g., depression)
  • Fatigue
  • Muscle soreness
  • Weight gain

There is some evidence that dutasteride can increase the risk of some breast and prostate cancers. When used off label in a topical form, systemic side effects of dutasteride are expected to be less frequent/severe, although no formal clinical studies have been done to confirm the safety and efficacy of topical dutasteride. The following is a list of possible side effects associated with the use of topical dutasteride:

  • Itching
  • Irritation
  • Dry and flaky scalp
  • Increased scalp oiliness

The above does not represent all potential side effects, medication interactions or study data relating to the safety of dutasteride. It is important to talk to your doctor, healthcare provider and/or pharmacist if you are experiencing any side effects. If you are experiencing a medical emergency or allergic reaction, call 911 or seek immediate medical attention. You are encouraged to report negative side effects of prescription products to the FDA. Visit or call 1-800-FDA-1088.
You can refer to the FDA prescribing information as well as the Prescriber’s Digital Reference (PDR) for comprehensive overviews of dutasteride.

* This page was medically reviewed by Dr. Christina Han, MD FRCPC.

* Topical dutasteride is a compounded medication and has not been approved by the FDA. Only available if prescribed after an online consultation with a licensed healthcare provider.

US Pat. no. 11,786,466

SiloxysSystem™ Gel

Our very own patented gel delivery system sets the new standard for managing hair loss. Uniquely designed to deliver medications slowly and over time and limit their absorption into the body. It's designed as a safer way to treat hair loss.

Learn About SiloxysSystem™

Real Patients. Undeniable Results.

Topical dutasteride results: before and after

See topical dutasteride regrowth results that members of the XYON community have achieved with our range of performance hair loss solutions.

XYON Reviews


Verified patient
XYON topical dutasteride patient before and after of crown area of the head
Norwood Scale (Hair Loss Type) 7 with diffused pattern alopecia 28 years old


Verified patient
XYON topical dutasteride patient before and after results of hairline
Norwood Scale (Hair Loss Type) 3 26 years old


Verified patient
XYON topical dutasteride patient shoqwing before and after results of top of his head
Norwood Scale (Hair Loss Type) 5 with diffused pattern alopecia 28 years old
illustration showing how XYON topical dutasteride blocks DHT

How does topical dutasteride treat male pattern hair loss?

Dutasteride treats hair loss by protecting hair follicles from the effects of DHT (Vano-Galvan et al., 2019). It's a potent blocker of the 5-alpha reductase enzyme, which is involved in converting testosterone into DHT. Compared with finasteride which only blocks one form of the enzyme, dutasteride blocks two forms. This can result in DHT reductions as high as 90% (Thomson, 2005).

Does topical dutasteride work for men?

Clinical data has shown that topical dutasteride and oral dutasteride may be effective options for treating pattern baldness in men.


men taking dutasteride experienced an improvement in BASP classification (a tool used to assess severity and type of hair loss).

Choi et al., 2022


more potent at blocking one type of the 5-alpha reductase enzyme compared to finasteride.

Gupta et al., 2022


increase in hair thickness after just 6 months of treatment with dutasteride.

Shanshanwal and Dhurat, 2017

A premium solution exclusive to XYON.

Technology designed to reduce dutasteride side effects.

Dutasteride has emerged as a potential highly effective treatment option for men experiencing pattern hair loss. However, because of its potential impact on hormone levels, dutasteride has also been associated with sexual side effects and mood changes, as well as potentially increased risk of high grade prostate cancers (Hirshburg et al., 2016). See how XYON's patented SiloxysSystem technology is designed to reduce the risk of systemic side effects.

Learn More About SiloxysSystem™
SiloxysSystem™ Gel - XYONHealth

SiloxysSystem™ Gel

Topical Finasteride Sprays & Solutions - XYONHealth

Sprays & Solutions




Targets delivery of hair loss treatments to the scalp and hair follicles, reducing medication absorption into the body.

Medications delivered in an uncontrolled way and may contain ingredients that increase absorption.

Expose the entire body to a medication. This could possibly increase the risk of side effects.

Delivery System

Timed-release technology ensures continuous administration of medication. Mess-free formula and lightweight texture.

No sustained delivery. Formulas may be messy and require several applications per day to be effective.

Pill form, taken by mouth. For those less concerned about side effects.

Application tips for Topical Dutasteride.

Here's how to make the most out of your hair loss treatment.

Visit the XYON Medical Library.

Stay up to date with our curated selection of medically-reviewed articles and resources on men's health and hair loss.

Frequently asked questions about Topical Dutasteride for hair loss.

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How to get Topical Dutasteride from XYON.

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